Prof. Dr. Fernando Luiz Affonso Fonseca | Health Professions | Best Researcher Award
Full Professor | FMABC University Center and Federal University of Sao Paulo | Brazil
Prof. Dr. Fernando Luiz Affonso Fonseca is a Brazilian hematology and oncology researcher whose work centers on genomic instability, cancer molecular diagnostics, and translational biomarker development. His contributions span breast cancer genetics, circulating cell-free DNA dynamics, tumor-derived DNA detection, and metabolic and obesity-related biomarkers with clinical relevance. He has advanced research on mononuclear cell fraction biology, mismatch-repair mechanisms, and molecular signatures associated with cancer progression. His work also extends to laboratory methodology, including validation of molecular assays, integration of biomarker panels into diagnostic workflows, and evaluation of precision-medicine tools such as multigene platforms for therapeutic decision-making. His recent studies include clinical–molecular investigations in oncology and immunometabolic conditions, emphasizing biomarker interpretation, molecular repair pathways, and public-health implications of diagnostic technologies.
Profile : Google Scholar
Featured Publication
Neto, A. S., Wroclavski, M. L., Pinto, J. L. F., Marsicano, S. R., Delgado, P. O., … Fonseca, F. L. A. (2012). Methodological standardization for the extraction of free DNA in plasma of peripheral blood.
Tsun, L. Y., Bibo, T. A., Veiga, G. L., Gaiatto, A. C., Moreira e Costa, N., Raimundo, J. R., … Fonseca, F. L. A. (2023). Quantification of vitamin D at different levels of clinical worsening of COVID-19.
Quidute, R., Quidute, P., Perez, M. M., Peiró, C. H. F., da Veiga, G. L., da Costa Aguiar Alves, B., & Fonseca, F. L. A. (2025). Mismatch repair system gene expression in FFPE samples from breast cancer patients.
Normando, S. R. C., Delgado, P. O., Rodrigues, A. K. S. B., David Filho, W. J., Fonseca, F. L. A., Cruz, F. M., & del Giglio, A. (2018). Circulating free plasma tumor DNA in patients with advanced gastric cancer receiving systemic chemotherapy. Journal of Clinical Oncology, 36(15_suppl), e24067.
Cubero, D. I. G., Fonseca, F. L. A., Alves Reis, B. C. A., Sousa, L. V. A., Maselli-Schoueri, J. H., & del Giglio, A. (2025). Cost-effectiveness analysis of the 21-gene platform for guiding treatment decisions for early hormone-positive breast cancer: The perspective of the Brazilian public health system. BMC Health Services Research.